MICHAEL ZELIGS, MD

SUMMARY

Michael A. Zeligs, M.D., is a physician-investigator with interest in the
field of nutritional intervention in aging processes. Apart from his experience in clinical pharmacology, his drug and nutrient delivery
research experience include patent applications for hormonal eye drops and vitamin-hormone combinations for aging skin. He has performed laboratory based studies in nutrient delivery as a consultant for the Immudyne Corporation and served as scientific advisor for NeoCare Laboratories.  Dr.Zeligs holds a M.A. degree in stress-physiology from the University of California, Santa Barbara, and an M.D. degree from the University of California, Irvine, College of Medicine.  Dr. Zeligs has completed specialty training in Anesthesiology, Pediatrics, and Immunology. His clinical research has focused on hormonal aspects of aging.  In this regard, he has served as sponsor-investigator for multiple Investigative New Drug Filings (IND) with the FDA for investigation of the use of Dehydroepiandrosterone (DHEA) to improve metabolism and immunity in the elderly.


I.        BACKGROUND:    (U.S.Citizen), Married, with four children. Residence:Boulder,   Colorado

II.      CURRENT HOSPITAL APPOINTMENTS:
Prior Chairman, Department of Anesthesiology,and, Staff Physician ,Pediatrics, Boulder Community Hospital, 1136 Alpine, Boulder, Colorado 80304.

Staff Anesthesiologist
Ambulatory Surgery Unit  (ASU)
Boulder Medical Center
North Broadway
Boulder, Colorado  80301

III.     SUMMARY OF RECENT RESEARCH TOPICS:
- Use of DHEA in Elderly Men to Improve            Immune Function, 1988.

- Influence of DHEA in Familial Hypertriglyceridemia, 1989.

- Topical DHEA for treatment of the Dry-Eye -Syndrome, 1990

- Influence of DHEA on Lipid Synthesis by Keratinocytes, 1991.

IV.   BOARD CERTIFICATION:

Entry Date:
        American Board of Anesthesiology,
6/84
        American Board of Pediatrics
7/84
        American Board of Allergy and Immunology,         eligible from 7/92

V.    U. S. MEDICAL LICENSURE:   Colorado (23543) and Hawaii (3446)

VI.     SUMMARY OF CLINICAL TRIALS RESEARCH EXPERIENCE:

-Sponsor, Principal Investigator,  I.N.D. #30,668 "Influences of
Dehydroepiandrosterone on Age-Related Changes in Lymphocyte Function", 1988   (Phase I)

-Sponsor, Principal Investigator,  I.N.D. #33,555 "Influence of DHEA in Treatment of Familial Hypertryglyceridemia", 1989  (Phase I)

-Sponsor, Investigator, I.N.D. #39,783 "Topical, Occular Use of DHEA in Treating the Dry-Eye Syndrome" 1992  (Phase I and II)

-Investigator, "Use of DDI in AID's Patients Intolerant to AZT", 1991(Phase III)

- Investigator, "Use of GM-CSF in AID's Related Granulocytopenia", 1991(Phase III)

VII.   SUMMARY OF PRIOR  HOSPITAL APPOINTMENTS:

Long Beach Memorial Medical Center and Miller's Childrens Hospital
2801 Atlantic Avenue, Long Beach, California -
Chairman and Vice-Chairman Departments of Pediatric and Adult Anesthesiology:
7/84 - 6/92

University of California, College of Medicine, Irvine, California
Clinical Instructor, Department of Anesthesiology: 4/86 - 6/92

Saint Joseph Hospital,  1835 Franklin Street, Denver, Colorado,
Staff Physician,  Departments of Anesthesiology and Pediatrics:
11/82 - 7/84

University of Colorado,  School of Medicine, Denver, Colorado
Clinical Instructor, Department of Anesthesiology  11/82 - 7/84

VIII.  POSTGRADUATE TRAINING:

Fellowship:
Division of Clinical and Molecular Immunology
Department of Medicine, University of California
Irv ine,  College of Medicine, Irvine, California
Research Fellow     7/88 - 6/91

Residencies:

University of Colorado,  Denver, Resident in Anesthesiology
Department of Anesthesiology    11/80 - 11/82

University of Hawaii, Department of Pediatrics and Resident and Fellow in Neonatology , Division of Newborn Medicine  7/78 - 6/80

University of California, Irvine, College of Medicine, Department of Pediatrics, Resident in Pediatrics, 7/77 - 6/78

IX.  EDUCATION:

1971:   B.A. (Cum Laude),   Zoology, Department of Biology, University of  California, Santa Barbara, California.

1972:   M.A.,  Physiology,   Graduate School of Biology, University of California, Santa Barbara, California.

1977:   M.D. College of Medicine, University of California, Irvine.

X.   ACADEMIC HONORS:

University of California, Irvine, College of Medicine, Alumni Scholarship, 1975-76.

XI.  SOCIETIES AND PROFESSIONAL MEMBERSHIPS:

American Society of Anesthesiologists.
Colorado Society of Anesthesiologists
American Academy of Pediatrics
American College of Allergy and Immunology
Colorado Medical Society
Boulder Medical Society
American College for Advancement in Medicine
American Academy of Anti-aging Medicine

XII:  FOREIGN LANGUAGES:    Spanish

XIII: FOREIGN ASSIGNMENTS:

Gorgas Hospital, Canal Zone, Panama: Externship in Internal Medicine,
1974.
Ministry of Health Hospital, LaMerced, Peru: Visiting Intern in General Medicine, 1977.

XIV.  PUBLICATIONS:

ARTICLES:
Zeligs, M.A., Wolfe, R.R., and Horvath, S.M.; "Hemorrhage, Altitude Adaptation and Polycythemia", Circulatory Shock, Volume 1,  No.
3, Pages 169-75,  1974

Crowell, D.H., Zeligs, M.A., Kapuniai, L.E., Hsia, Y.E., "Autoregressive Estimation of Brain Maturational Level in Severely Impaired Children"
Proceedings of the 5th International Assocaition of the Scientific
Study of Mental Deficiency  (IASSMD) ,  1979.

Zeligs, M.A.,  Lockhart, C.H. "Propranolol Associated Hypoglycemia in Children: Case Report and Review", Anesthesia and Analgiesia, Vol. 62, pages 1035-37, 1983.

Zeligs, M.A., Choy, A., and Rosales, T., "Tetracaine to Prevent Post-Anesthetic Emesis after Strabismus Surgery", Journal of Pediatric
Ophthamology and Strabismus,  1989.

Zeligs, M.A., "Diet and Estrogen Status: the Cruciferous Connection", Journal of Medicinal Food, Vol. 1, No. 2. , pages 67- 82, 1998.

ABSTRACTS:

Zeligs, M.A. and Shanberg, A. "Caudal-Epidural Injection of Morphine-Sulfate for Post Operative Pain Control in Infants and Children",
Proceedings, Anesthesiology Section, American Academy of Pediatrics, April, 1990.

Zeligs, M.A. and Shanberg, A. "Pediatric Use of a Micro-Catheter for Continuous, Caudal-Epidural Anesthesia and Narcotic Analgesia",
Proceedings, Anestheisiology Section, American Academy of Pediatrics, April, 1990.

Zeligs, M.A., Kalayjian, R.W., and Solomon, J.M., "Dose Requirements for Continuous, Caudal-Epidural Narcotic Analgesia in Young Children", Journal of Pain and Symptom Management,  1990.

Zeligs, M.A. and Vayavegula, B., and Gupta, S.,
"Dehydroepiandrosterone(DHEA) has Dose-Related Effects on Mitogen Stimulated
Lymphocyte Proliferation  In-Vitro", Annals of Allergy, Vol. 64 Number 1, page 83, 1990.

BOOK CHAPTERS:

"Aging and Adaptation - The Role of Dehydroepiandrosterone (DHEA) and Melatonin as Hormonal Determinants of Aging"
Submitted to the American Physiological Society,
Handbook of Physiology Series, 1993.

UNPUBLISHED RESEARCH:

Zeligs, M.A. and Wilson, A.F.; "The Use of Acetylene in the Measurement of Lung Tissue Volume", Department of Medicine, University of California, Irvine, 1975.

Zeligs, M.A., "Outcome of Infants Born to Mothers treated with Terbutaline for Premature Labor", Department of Pediatrics,
University of Hawaii, 1979.

Zeligs, M.A. and Vayuvegula, B., "Influences of Dehydroepiandrosterone on Age-related Changes in Lymphocyte Function", Long Beach Memorial Research Foundation and University of California Irvine, 1990.

XV.  INVITED PROPOSALS AND PRESENTATIONS:

5/87  Approval of proposal by the Long Beach Memorial Research Council: "Use of Dehydroepiandrosterone (DHEA) to treat complement activation in recent onset   diabetics"

12/87 Preparation of proposals for transdermal, intranasal, and aerosolized, and sustained release Dehydroepiandrosterone, submitted to
University of California Patent Office.

7/89  Preparation of proposal for Melatonin (N-Acetyl Mehoxytryptamine):
"Use of Melatonin to improve sleep and immune function  in the elderly".

8/90  Presentation to Daleco International Corporation, Newport Beach,
California:"Potential New Uses of
Dehydroepiandrosterone (DHEA)".

9/90  Proposals and cell culture trials combining DHEA and Glucans using human white cells and tumor models, Long Beach Memorial, Cancer Research Institute.

12/90 Submission of Small Business Innovation and Research Grant Application (SBIR):"Development of Sustained-Release DHEA".

2/91   Proposal and animal testing of a prototype DHEA preparation of eye-drops treating eye disorders in animals.

7/93   Presentation to Boulder Medical Center Staff: "Hormonal and Immuno-Pharmacologic Aging Intervention."

10/93 Presentation to Global Drug Development, Ltd., Denver, Colorado:"New Clinical Uses for DHEA and Retinoids".

10/96 Presentation to Boulder Community Hospital Professional Staff:"Usefulness of Melatonin: Separating Fact from Fancy"